medintp

Latest Posts by medintp

Forgot I made these quick refs once!! It’s not that you should feel obligated to portray every part of an animal correctly, but in some cases these are very unique, interesting features that very few artists are ever utilizing creatively!

anyway i had a really stupid idea, tag me if you end up making a character/illustration using this!

Antimicrobial Agents  - Cell wall inhibitors

Based on mode of action • divided into families based on chemical structure

 Modes of action Interference with: 

cell wall synthesis 

protein synthesis 

nucleic acid synthesis 

plasma membrane integrity 

metabolic pathway 

Inhibitors of Bacterial Cell Wall (peptidoglycan) Synthesis 

The Beta-lactam Family 

The Glycopeptides 

Peptidoglycan is composed of N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM) repeat units, and amino acids.  Each NAM is linked to peptide chain and the peptide chains are cross-linked.

β-lactams 

Includes penicillin derivatives (penams), cephalosporins (cephems), monobactams, and carbapenems.

class of broad-spectrum antibiotics containing a β-lactam ring

Bacterial transpeptidase enzymes are responsible for catalysing cross-linking of the peptide chains

β-lactam ring bind to these transpeptidases – this inhibits cross-linking between peptide chains and prevents synthesis of stable PG

Cell wall synthesis ceases and the bacterial cells eventually die due to osmotic instability or autolysis. 

Glycopeptides 

Polypeptide agents - basic structural elements amino acids 

Vancomycin: 

complexes with peptide portion of peptidoglycan’s precursor units 

vancomycin is a large hydrophilic molecule able to form hydrogen bonds with the terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides

preventing PG transglycosylation reaction – PG precursor subunits (NAG-NAM+peptide) cannot be inserted into peptidoglycan matrix;

Vancomycin also alters bacterial-cell-membrane permeability and RNA synthesis

Uses:  serious Gram positive infections e.g. MRSA wound infection

Adverse effects:

damage to auditory nerve 

hearing loss (ototoxicity) 

“Red man/neck” syndrome - rash on face, neck, upper torso 

Antimicrobial Agents - Inhibition of DNA and Protein Synthesis

Bacterial chromosome replication

DNA replication

Bacterial Topoisomerases 

maintain DNA in appropriate state of supercoiling 

cut and reseal DNA

DNA gyrase (topoisomerase II) introduces negative supercoils 

Topoisomerase IV decatenates circular chromosomes 

these are the targets of the quinolone antibacterial agents 

Quinolones

bind to bacterial DNA gyrase and topoisomerase IV after DNA strand breakage 

prevent resealing of DNA 

disrupt DNA replication and repair 

bactericidal (kill bacteria)

Fluoroquinolone is particularly useful against

Gram +ves: Staphylococcus aureus, streptococci 

Gram -ves: Enterobacteriacea; Pseudomonas aeruginosa 

Anaerobes: e.g. Bacteroides fragilis 

many applications e.g. UTIs, prostatitis, gastroenteritis, STIs 

Adverse effects

Relatively well tolerated

GI upset in ~ 5% of patients 

allergic reactions (rash, photosensitivity) in 1 - 2% of patients 

Inhibition of Bacterial Protein Synthesis 

Macrolides 

in 1952: Erythromycin was isolated as the first macrolide (Streptomyces erythreus) 

Newer macrolides: clarithromycin, azithromycin 

Structurally they consist of a lactone ring (14- to 16-membered) + two attached deoxy sugars 

Mode of action 

bind reversibly to bacterial 50S ribosomal subunit 

causes growing peptide chain to dissociate from ribosome → inhibiting protein synthesis 

bacteriostatic (stops reproduction)

Macrolides’ spectrum of activity

good antistaphylococcal and antistreptococcal activity 

treatment of respiratory & soft tissue infections and sensitive intracellular pathogens • e.g. Chlamydia, Legionella 

Adverse effects

Generally well tolerated

nausea 

vomiting 

diarrhoea 

rash 

Aminoglycosides

large family of antibiotics produced by various species of Streptomyces (“mycin”) and Micromonospora (“micin”) 

include: streptomycin, neomycin, kanamycin, gentamicins, tobramycin 

Structure = linked ring system composed of aminosugars and an aminosubstituted cyclic polyalcohol 

Mode of action of aminoglycosides

Bind irreversibly to 30S ribosomal subunit 

disrupt elongation of nascent peptide chain 

translational inaccuracy → defective proteins 

bactericidal 

Spectrum of activity 

broad spectrum; mainly aerobic G-ve bacilli (e.g. P. aeruginosa) 

used to treat serious nosocomial infections (hospital acquired infections)

First TB antibiotic

Used for cystic fibrosis 

Adverse effects

all aminoglycosides have low Therapeutic Index (only a small amount needed to become toxic)

renal damage, ototoxicity, loss of balance, nausea 

Pregnancy - physiology

Hormones

hCG - human chorionic gonadotropin - present in blood and urine, produced by blastocyst and placenta

Low levels of hCG could mean miscarriage, ectopic pregnancy, miscalculation of dates

High levels = molar pregnancy (cells that normally form a baby dysfunction and form cysts instead), multiple pregnancy (twins etc), miscalculation of dates

Progesterone increases fat deposition in early weeks and stimulates appetite

Increased oestrogen from corpus luteum promotes mammary gland development (breasts enlarge)

And inhibits ovulation via negative feedback [OES decreases GnRH release by hypothalamus –> linhibition of FHS and LH –> no ovulation]

Relaxin (secreted by corpus luteum) softens connective tissue in preparation for labour - not specific, all joints can be affected

Peaks in early and late pregnancy

Physical changes

Blood pressure

As early as 4 weeks into pregnancy 

plasma volume increase

caused by the affects of oestrogen and progesterone on the kidneys

OES and Prg cause vasodilation 

less resistance = less pressure

Heart rate increases by 25% to compensate

stroke volume increases 

increased overall cardiac output by 50% in third trimester

Direct action of enlarged uterus:

compresses the descending aorta and inferior vena cava 

decreased venous return - less blood in means less blood out, less blood in ventricle –> reduced pressure on walls –> reduced force to exit –> reduced placental perfusion

increased aortic pressure

increased heart rate

[shouldn’t sleep on back for this reason]

Outcomes:

Fall in blood pressure (can cause collapse if serious)

Can cause foetal hypoxia even without mother symptoms

Haematological changes

red cell mass increase by 20% (renal - increased erythropoietin production in response to detection of blood oxygenation and sodium/water balance)

Plasma volume increases more than RBC count does, causing the impression of decreased haemoglobin (anaemia)

Increased tendency to clot (hypercoagulable)

due to increase in clotting factors and plasma fibrinogen

platelet production increase (however count drops due to increase in activity and consumption) - function remains normal]

WBC count may increase due to an increase in granulocytes

Respiratory changes

Increased chest diameter, diaphragmatic expression and elevation

dyspnoea common (difficulty breathing)

breathing becomes more costal (mouth) than abdominal 

mainly mediated by progesterone levels (cause bronchial and smooth muscle relaxation and hypersensitivity to CO2)

Changes to the urinary system

cardiac output increase –> increase in renal plasma flow and glomerular filtration

increase in urea, creatinine, urate and biocarbonate clearance 

with progesterone, renin and aldosterone up water retention increases

can lead to urinary stasis and increased risk of UTI

Any drugs given that are excreted renally must be given in much higher quantities consequently

Gastrointestinal changes

Appetite increase + cravings 

Gastric reflux sphincter relaxation (increased indigestion, also due to increased intra-gastric pressure (expanding uterus)) 

gallbladder dilated 

GI motility decreased and transit time slower 

albumin and protein decrease 

cholesterol twice normal value

Muskuloskeletal 

Calcium reuptake into bloodstream results in mild decalcification of bones 

relaxin softens joints (pubic symphysis + alters gait (waddling))

abdominal muscles stretch to elastic limit 

stretch marks (stria gravidarum) caused by rupture of elastic fibres and small blood vessels 

Reproductive changes

Massive increase in mass

Placenta growth (nutrition, excretion, immunity, endocrine) 

Parental blood supply 

Anti-cancer drugs - DNA targeting

Include alkylating agents, intercalating agents, and chain cutters.

Alkylating agents

Highly electrophilic species, looking for nucleophilic sites to attack, and forming covalent bonds to bases in DNA 

Prevent replication and transcription 

Toxic side effects (e.g. alkylation of proteins) 

Bind in the major groove of DNA

Both types cross-link DNA by covalently bonding to nitrogen of base pairs.

Binding of nucleic acid bases results in miscoding and distortion. 

Distortion of DNA prevents excision by HMG proteins – permanent damage. 

Transcription and replication prevented, tumour growth slows. 

Two electrophilic sites on an anticancer drug can cause interstrand and intrastrand cross-linking.

Preference for 1,2-GG or 1,2-GC linkage sites, with interstrand or intrastrand linkage, is dictated by drug chemical structure 

Other linkage adducts are possible. Eg 1,3-GCG, 1,2-GA. 

Monofunctional adducts are also possible 

Chlormethine (a nitrogen mustard)

 Chlormethine is highly reactive, toxic side effects. 

Lead compound for many less toxic mustard derivatives. 

Methyl (CH3 ) group has positive inductive effect – promotes loss of chloride – see mechanism 

Less toxic chlormethine analogues:

Melphalan:  e- withdrawing ring lowers Nu strength of N, less reactive drug, less side effects, less toxic. Mimics PhAla, carried into cells by transport proteins. 

Uracil mustard:  Uracil ring is e-withdrawing, less reactive alkylating agent. Mimics a nucleic acid base, concentrates in fast growing cells.

Cyclophosphamide:  Most commonly used alkylating agent, Non-toxic, orally active prodrug. Acrolein associated with toxicity.

Busulfan: Causes interstrand cross-linking. Sulphonate group withdraws electrons, adjacent carbon subject to Nu attack by DNA bases. 

Dacarbazine – A diazine:  Prodrug activated by oxidation in liver, decomposes to form methyldiazonium ion. Alkylates guanine groups 

INTERCALATING AGENTS

 Aminoacridines eg Proflavine

Antibiotics - Dactinomycin

Extra binding to sugar phosphate backbone by cyclic peptide 

Intercalates via minor groove of DNA double helix 

Prevents unwinding of DNA double helix 

Blocks transcription, blocks DNA-dependent RNA polymerase 

Anthracyclines eg Doxorubicin (adriamycin) 

 Extra binding to sugar phosphate backbone by NH3 Planar rings and Anthracyclines eg Doxorubicin (adriamycin) 

Intercalates via major groove of DNA double helix 

 A topoisomerase poison - blocks action of topoisomerase II by stabilising DNA-enzyme complex 

CHAIN CUTTERS 

Calicheamicin g1 I antitumour agent 

 Nucleophilic attack on trisulphide chain starts a rearrangement process. 

This interacts with DNA to generate a DNA diradical, which reacts with oxygen, resulting in chain cutting.

Bleomycins (BLM)

Highly active head, neck, testicular cancer (Hodgkin lymphoma) 

Single and double-strand cleavage of DNA with several reduced metal ions and O2 , Fe(II) highest in vivo activity. 

Three regions - 

bithiazole DNA binding domain (DBD) locks BLM into the minor groove, 

carbohydrate domain (CHD) H-bonds BLM to sugar phosphate of DNA 

metal binding domain (MBD) bonds to Fe(II)    

Mechanism

A reaction with hydrogen peroxide gives Fe(III) and hydroxyl radicals which abstract H atoms and cut the DNA chain. 

Fe2+ + H2O2 Fe3+ + OH. + OH− Fenton mechanism 

Lungs and skin have low levels of BLM hydrolase - higher sensitivity and toxicity. Pneumonitis occurs in about 10% of patients, progresses to pulmonary fibrosis. Over-expressed in malignant cells, resistance to bleomycin    

Summary of Anti-Tumour Specificity for DNA 

Major groove alkylators 

GG interstrand - N-mustards, nitrosoureas. 

GG intrastrand - methanesulphonates. 

GC-interstrand - nitrosoureas, triazines. 

Minor groove intercalators 

GG interstrand – anthracyclines. 

GC-interstrand – actinomycins, acridines. 

Minor groove chain cutters 

GC or GT intrastrand – bleomycins 

BELLAMY BLAKE IS GETTING HIS WIFE BACK

Iconic Bellarke lines

To get you through these tough times, until Bellarke is an official ship.

1. Bellamy: If I’m on that list, you’re on that list. Write it down or I will.

2. Bellamy: Clarke, If I don’t see you again-

Clarke: No, You will

3. Bellamy: We can’t lose Clarke! We can’t lose her.

4. Clarke: You’ve got such a big heart Bellamy. People follow you, you inspire them because of this (Touches his heart). But the only way we’re gonna get through this is if you use this too (touches his head).

Bellamy: I got you for that.

5. Clarke: The Heart and the Head.

Bellamy: The Heart and the head

6. Bellamy: I was so mad at you for leaving. I don’t want to feel that way anymore.

7. Bellamy: Besides, I could use a break from keeping you alive.

Clarke: Thank you for keeping me alive.

Bellamy: Well, you don’t make it easy.

8. Diyoza: 283 lives for one. She must be pretty important to you.

Bellamy: She is.

9. Jaha: She’s lucky to have you. You keep her centred.

Bellamy: You got it backwards.

10. Bellamy: Together.

so I got into grad school today with my shitty 2.8 gpa and the moral of the story is reblog those good luck posts for the love of god

Mind blown 😂

“If we break up, I want closure. None of this bitter high school mentality that usually follows after someone leaves. I want a long talk about what went wrong, why we couldn’t fix it, and how we’ll move on afterward. I want to know how I made you feel and what thought-process led you to the decision that you’re making. Because if I spent a fraction of my life devoted to loving you, you can’t expect me to let you go without any explanation as to why you’re going in the first place. If I love you, there will always be a piece of me that loves you. So let’s talk it through and forgive each other, neither of us are perfect and we’re both still learning how to love. And that’s okay, it is. But instead of seeing each other the next day and awkwardly pretending we weren’t ever anything at all, let’s forgive each other now and move on. Make peace.”

— Car thoughts #150

guys… I don’t know if you know this but… if you wake up early… there’s so many more hours in the day

The Night Before a Big Exam.

long time no text post huh?

For all my new followers, hello I’m Nadine I’m 23 years old and I’m finishing my fifth year in medschool where I go it’s six years right after high school. And a few days ago y’all probably saw me freaking out the night before a big test.

I was panicking so much because that teacher is notorious for his larger than life exams and surgery really isn’t my forte here but I just got my results back, they were very interesting and they led me to an important conclusion that I wanna share with you. Let me break it down first

I had all of my guides ready (here is a post on how I make them) and for the week before my exam I was studying consistently (so reading my guides in the morning and doing some MCQs at night). Mind you I usually only do one study session per day but I’d really pushed myself this time and as I was going to bed 2 days before my test I had finished 19 out of the 25 topics I needed to get done.

So when I woke up the next day (24 hours till major squashfest test) I felt literally sick, my head was hurting really bad, I believe it was a tension headache, self diagnosis I mean I’m almost a doctor right, and I got my period and we all know how awful that first day is. My original plan was to go over the 6 VERY little chapters I had left (as I mentioned in my how to study for finals post I usually start with what I know least/the hardest chapters and leave the easier and shorter stuff towards the end, a strategy I fucking swear by) so my plan was to get these done in 4 hours or so and then revise for the whole day.

Obviously things did not go according to plan because I was having a terrible headache + all of your standard first day of period shit and I was only able to get these 6 little chapters done by 12 am that night (so 8 hours till the godforsaken test).

I woke up the day of the test, got ready and went to uni and I kid you not I have never been so fucking terrified in my life over an exam because I usually take comfort in the fact that I had done my best and literally for those past 24 hours I had only gotten in 3.5 hours of very mediocre studying and there were some things that I had last went over a week ago (!!), how the hell am I gonna remember them was the only thing on my mind the entire day. I was so exhausted from pushing myself so hard all week plus my period and it was all too much.

Fast forward a few hours later, exam done, I felt horrible afterwards, I thought I was going to fail so I just took a looooong ass nap and then woke up and got myself a chocolate frap. Then I got my results and I actually had done pretty well. 87% is not my best but it’s a fucking good grade and I was so proud.

So where’s the lesson here

IT IS NOT JUST ABOUT THAT ONE NIGHT BEFORE AN EXAM. It’s honestly something I’ve believed in my entire life, the night before a big test you just revise revise revise until you go to bed, you wake up and revise revise revise until you’re inside the exam hall, that’s just how it’s been for me my entire life and this experience taught me that it’s okay if you don’t get a chance to go over everything the night before a test and as long as you’ve put in the work at some point and get plenty of sleep you should be good to go. I’ve said it before and I’ll say it again all nighters are THE DEVIL they do not work they just fuck you up. So yeah, let’s all try and not be so hard on ourselves the night before an exam, take it from me if you’ve put in the work just get enough sleep and you’re good. One night did not cancel out a week of hard work for me and I’m sure it won’t for you. Take it from someone who’s been there, just go to bed.

The International Space Station: Apex of International Collaboration

It’s National Space Day! To mark the occasion, we’re reflecting on the International Space Station, which has been continuously occupied since Nov. 2, 2000. As our orbiting laboratory that enables us to conduct important science off our home planet, the ISS allows researchers from all over the world to put their talents to work on innovative experiments in the microgravity environment. An international partnership of space agencies provides and operates the elements of the ISS. The principals are the space agencies of the United States, Russia, Europe, Japan and Canada. Although each space station partner has distinct agency goals for station research, each partner shares a unified goal to extend the resulting knowledge for the betterment of humanity! Here are 5 fun facts about our about our out-of-this world floating laboratory:

1. The ISS is a unique scientific platform that has enabled more than 3,600 researchers in 106 countries and areas to conduct more than 2,500 experiments in microgravity through February 2018—and the research continues. 

2. Astronauts and cosmonauts have conducted more than 205 spacewalks (and counting!) for space station construction, maintenance and repair since December 1998.

3. The station’s orbital path takes it over 90 percent of the Earth’s population, with astronauts taking millions of images of the planet below. 

4. Six spaceships can be connected to the space station at once.

5. An international crew of at most six people live and work while traveling at a speed of five miles per second, orbiting Earth about every 90 minutes.

Currently, six humans are living and working on the International Space Station, which orbits 250 miles above our planet at 17,500mph. 

Make sure to follow us on Tumblr for your regular dose of space: http://nasa.tumblr.com.

Ugh #2

Pros and cons of having a mental illness

Pros: nothing anybody ever tells you can really really get to you.

- professor telling you you are stupid and worthless. Dude dont worry ive been telling that myself for years

- grades telling you you suck and you should rethink being a student. Yeah yeah i know i should

- family telling you you are weird and tiring. Tell me something i dont know

Cons: literally everything else

Ugh #1

Fucking up when you knew you would is so funny.

Your depression is there to tell you you are a worthless piece of shit who has to fuck other people up.

But you are ready.

Anxiety already prepared you for fucking up. 😝 you knew that would happen

What Loving someone when you have anxiety is really like.

What if you know you found the one, but every minute of the day feel like you don’t deserve them because you are worthless and not believing a single thing of what they say to you, because past relationships messed you up so bad that you have trust issues. Seeing every compliment as a lie because in your head it is simply not possible for someone to look at you that way. You make up the worst scenarios in your head of them leaving you, but you are too scared to tell them because they might actually do. Waking up every single night crying because in your dreams they don’t want to be with you, like you always expected. It feels like loving me is a job not something you do because you actually love me. I worry about everything. I overreact half of the time and I push you away when I need you the most. I need constant reassurance and god I hate it so much. There is always this fear of not knowing what someone actually thinks about you because the voices in your head are screaming at the sweet words he tells you. I say ‘sorry’ 20 times a day because I actually think I insulted you in some way and the smallest arguments seem like the end of the world. I cry and panic over the smallest things and I ask if I am annoying at least 3 times a day because I believe I am. I cry every time you have to go home or when you leave because it might be the last time I get to see you even though I know that’s not true. I never expected finding the love of my life would also be one of the most painful things ever.

I believe in free education, one that’s available to everyone; no matter their race, gender, age, wealth, etc… This masterpost was created for every knowledge hungry individual out there. I hope it will serve you well. Enjoy!

FREE ONLINE COURSES (here are listed websites that provide huge variety of courses)

Alison 

Coursera

FutureLearn

open2study

Khan Academy

edX

P2P U

Academic Earth

iversity

Stanford Online

MIT Open Courseware

Open Yale Courses

BBC Learning

OpenLearn

Carnegie Mellon University OLI

University of Reddit

Saylor

IDEAS, INSPIRATION & NEWS (websites which deliver educational content meant to entertain you and stimulate your brain)

TED

FORA

Big Think 

99u

BBC Future

Seriously Amazing

How Stuff Works

Discovery News

National Geographic

Science News

Popular Science

IFLScience

YouTube Edu

DIY & HOW-TO’S (Don’t know how to do that? Want to learn how to do it yourself? Here are some great websites.)

wikiHow

Wonder How To

instructables

eHow

Howcast

MAKE

Do it yourself

FREE TEXTBOOKS & E-BOOKS

OpenStax CNX

Open Textbooks

Bookboon

Textbook Revolution

E-books Directory

FullBooks

Books Should Be Free

Classic Reader

Read Print

Project Gutenberg

AudioBooks For Free

LibriVox

Poem Hunter

Bartleby

MIT Classics

Many Books

Open Textbooks BCcampus

Open Textbook Library

WikiBooks

SCIENTIFIC ARTICLES & JOURNALS

Directory of Open Access Journals

Scitable

PLOS

Wiley Open Access

Springer Open

Oxford Open

Elsevier Open Access

ArXiv

Open Access Library

LEARN:

1. LANGUAGES

Duolingo

BBC Languages

Learn A Language

101languages

Memrise

Livemocha

Foreign Services Institute

My Languages

Surface Languages

Lingualia

OmniGlot

OpenCulture’s Language links

2. COMPUTER SCIENCE & PROGRAMMING

Codecademy

Programmr

GA Dash

CodeHS

w3schools

Code Avengers

Codelearn

The Code Player

Code School

Code.org

Programming Motherf*?$%#

Bento

Bucky’s room

WiBit

Learn Code the Hard Way

Mozilla Developer Network

Microsoft Virtual Academy

3. YOGA & MEDITATION

Learning Yoga

Learn Meditation

Yome

Free Meditation

Online Meditation

Do Yoga With Me

Yoga Learning Center

4. PHOTOGRAPHY & FILMMAKING

Exposure Guide

The Bastards Book of Photography

Cambridge in Color

Best Photo Lessons

Photography Course

Production Now

nyvs

Learn About Film

Film School Online

5. DRAWING & PAINTING

Enliighten

Ctrl+Paint

ArtGraphica

Google Cultural Institute

Drawspace

DragoArt

WetCanvas

6. INSTRUMENTS & MUSIC THEORY

Music Theory

Teoria

Music Theory Videos

Furmanczyk Academy of Music

Dave Conservatoire

Petrucci Music Library

Justin Guitar

Guitar Lessons

Piano Lessons

Zebra Keys

Play Bass Now

7. OTHER UNCATEGORIZED SKILLS

Investopedia

The Chess Website

Chesscademy

Chess.com

Spreeder

ReadSpeeder

First Aid for Free

First Aid Web

Wolfram Demonstrations Project

Please feel free to add more learning focused websites. 

*There are a lot more learning websites out there, but I picked the ones that are, as far as I’m aware, completely free and in my opinion the best/ more useful.

people who can graciously hide that they don’t like people are so terrifying. last year while working on tech for a play i asked my friend how he became friends with another guy on the crew and he got quiet, looked straight into my soul and said “he’s not my friend. i fucking hate him.” i lost 5 years of my life

Me, thinking about high school:

becoming an adult cheat sheet!!!

learn how to coupon

how to get free therapy

clean bathroom tips

what to do when you can’t pay your bills

learn time management skillz

recipes that take 30 minutes or less

see if you’re paying too much for your cell phone bill

create a resume

how to make a doctor’s appointment

organize your closet

find the right career

a list of stress relievers

how to pick a major

how to take care of yourself when you’re sick

things to bring to a doctor’s appointment

what the hell is a mortgage?

buying a used car

how to pick a health insurance plan

read the news

leave your childhood traumas behind

how to quit smoking

a list of hotlines in a crisis

what to expect from your first gynecologist appointment

what to do if you get pulled over by a cop

things to keep in your car in case of an emergency

I’m so happy for you!

Lmao what did Ariana do that means she needs to get booed at Manchester?

google is free and this article does a good job of explaining but because i dont want anyone to continue to give this girl money for being shit person, here we go.

besides being a cishet white woman HEADING a PRIDE EVENT (Which is something i shouldnt need to explain why its bad.. pride is by and for lgbt people and should not be HEADLINING a cishet.) 

Racism

this is her like 5 years ago vs her now. she is a white girl wearing blackface.  and before you go “thats not blackface! thats just a tan!!!” 

this is her on stage next to nicki minaj, a black woman. she is darker than nicki minaj. this is what a tan looks like

a tan is supposed to give you a more golden sun touched look, NOT MAKE YOU LOOK LIKE A DIFFERENT RACE! (also tan is a golden/yellow brown, not a deep brown… this is not an accident)

her hair, by the way, is in fact exensions. again, making her hair thicker and darker in order to pass as a poc… she steals from black musicians too… like its not news that white people steal culture from poc then market it as a new trend but… she really takes it to a whole new level and acts as if her new look is some fucking brand she made. 

remember shen she got a tattoo for 7 rings but didnt finish it and said “oh thats just fine :)” ? 

transmisogyny

in her video “thank you next” she has a man in a dress stereotype for a trans girl, then painted said person as desperate for a date.  this is a transmisogynist caracature. she is a cishet girl. this is transphobic. end of discussion.

homophobia

shouldnt have to explain why a het girl using sexualized lesbians that look like they came out of a porno for men in a music video for views isnt ok.

etc

she ignores when everyone first tried to tell her NICELY that what she was doing is wrong but as soon as people got less than kind about it, got all guilt trippy like a 3 yr old and went “why cant we just all get along its so sd to see people hating like this :(((((( be nice :(( “ 

she is friends with Pierce Morgan (known facist) and is QUITE PUBLIC ABOUT THIS, she constantly preaches the “we should just sit down and talk to people who are flaming bigots. their bigotry is just a difference of opinions ❤️❤️❤️” which is propaganda created by, surprise, the very bigots it refers to. if we dont fight or get upset then they can continue to be horrible people without consequence. 

she is now INSISTING on headlining pride, and i have seen more homophobic people than i can count say theyre going to buy tickets to pride just to see her. let me repeat that. homophobes are going to pride to see a homophobic artist. this is disgusting. this puts every gay and trans person there in danger. actually, it puts everyone there in danger because it is a pride event and any homophobes will see you there and assume youre gay anyhow so! 

tldr: ariana grande is a racist, transphobic, homophobic white girl parading around in blackface and appropriates black, latino, and asian cultures for $$$ and uses lgbt people for views.

are you a pink lemonade gay or a vanilla coke gay? sword gay or axe gay? cats and dogs gay or snakes and lizards gay? string lights gay or neon lights gay?

tag yourself: note takers edition

Takes digital notes: tries to keep up with notetaking but eventually falls behind after 5 lectures, drinks coffee only to stay awake, tries the aesthetic of drinking hot tea while taking notes but fails, wakes up early once in a century and thinks they’ve reached their peak, wants a better organisation system but is too tired, worries about studyspo for 2 mins before saying fuck it

Takes handwritten notes: have really nice handwriting but they don’t realise it themselves, headers!! are!! everything!!, have a love-hate relationship with taking notes, studying only when they feel like it, only writes key points as notes because everything else is too much, drifts off a lot while notetaking to daydream

Doesn’t take notes: wears hoodies like 90% of the time, tries really hard to take care of themselves but it’s hard™, hair in a bun because hairstyles?? too much work, yells “fuck the system” as they study more than anyone else, studies straight from books and Knows what to study, can’t study for more than 45 mins at a time, is productive nonetheless, kinda exhausted but still carrying on

Takes notes only in class: take! notes! in! class! save! your! time! fuckers!, in a constant state of chaos but they’ll never admit, have a great relationship with the professors, raises eyebrows at everything it’s a Brand, likes lunch dates a lot, hates people who talk during lectures, wants a vacation already

Is still rotating between handwriting and typed notes: “did we have any homework” at the beginning of every lecture, is really friendly but tired of everything, likes laughing at stupid jokes, hates studying but is still doing it anyway, Major Chaos™, everyone loves them but they don’t have a lot of close friends, will fight for their friends to death, the mood: they’re just being their ball of anxiety, let them live thnx

okay, here’s a really cool concept:

You’re ridiculously confident. Confident enough to not give a single eff about what they’re thinking when you go do the crazy things that you do.

You’re brave. Brave enough to stay true to your deepest values and desires where most follow the crowd blindly.

You’re insane, or at least that’s what they call you. Insane to want big dreams and then chase them with all of your might when others are still stuck in cages of self-doubt and hesitance.

You’re kind. Kind enough to portray your compassion and true humanity in a world where most are living fake, plastic lives and refuse to show just a little more kindness.

You’re beautiful. Always were and always will be. Your eyes sparkle with hope and positivity and your smile is angelic. When you laugh, it’s pure joy, and seeing you happy makes others happy as well.

You’re strong. Strong enough to get through all the difficulties and resistance you’re experiencing now and find faith and love on the other side.

You’re capable, wildly capable. Capable of your dreams and the desires that keep you awake at night, keep you alive. You truly deserve to make them a reality.

But most importantly, you’re free. Free now. Alive now. You have the freedom, the time and the responsibility to choose what kind of a person you want to be today when you go out into the world. So choose now. And choose to be the real you, not someone else that people have made you believe you are. Choose.

If you're tired, read this. Please.

Hey, amigo.

It’s hard, isn’t it?

I know. Sometimes, it’s painful too.

Sometimes you really wanna give up, throw the books, hide in a corner and never take any action again.

I understand. I really do.

But I’m not here to collaborate on the pity party. I’m not going to join in on the groaning challenge, or complain about how hard it is.

First, get this though. It is hard. I won’t lie. It is worth groaning upon. Maybe one or two pity parties are affordable too.

Yet, there’s a pact we’ve make together, and I’d like to remind you of it, before we talk further. New here? We call it the Shush Pact.

Don’t do it. Don’t complain. Don’t whine. Don’t give in so easily. Don’t.

Go ahead. Make the pact. Now.

Go on! Do it.

Tell yourself, today’s hard. Tiring. But, I won’t give in to this. Nor will I complain and moan about it, and waste my energy. Not today, Amelia! Today’s not that day.

Done?

Sure?

Okay. Let’s go.

If you’re tired.

If you’re tired, exhausted of the hustle, and almost at your breaking point, I want you to remember how MUCH this means to you.

I don’t know what’s driving you nuts. Maybe it’s a math problem you just can’t crack. The presentation due next week that isn’t up to the mark. Maybe it’s 3 gigantic books you have to read up on before your next theology class. Perhaps your business has come at a standstill, and you can’t get it to grow. Or maybe you hate your job, and have finally, bravely, taken the step to work the 6 hours after you come home on building the art portfolio of your dreams, because in your heart, you’ve always been an artist. Maybe you’re juggling three jobs and working late nights to save enough money to catch the dream bus.

I don’t know. But I do know that it means a lot to you.

I know how passionate you’re about this, and how much it means to you.

And yet, you’re tired.

You’re tired of it!

You’re tired of studying so much. You’re tired of DMing every business in town, to have none reply back. You’re tired of working so much, handling so much, and you feel like you haven’t had a break since you were a kid. You’re tired of the pressure, you’re tired of the hustle and you just… wanna quit.

Don’t.

Please.

It’s hard to be positive in this dark, numb time and you’re starting to work mechanically, questioning your existence with every hour, but I have to make you understand! You’re worth this! You’re so worthy of this, my love.

Please don’t quit.

Don’t give up. It’s hard, but seal those lips, and trust your gut. I know you can make it. You’ve worked so hard for this! You’ve struggled so much, invested in so many weeks of work, and right now, at your breaking point, I want you to realise that you’re worthy. Of getting that grade, that degree, finding a job you love, your crazy ambitions of opening a flower shop… everything! All of it!

You deserve the world.

Listen to me. Open your ear and listen: you’re tired, yes. But here’s the truth. You’re not done yet.

You’ve got so much to prove to yourself. So many identities to identify yourself with. Exams to slay, jobs to get, money to make, dreams to build, people to meet and love to spread.

Listen. There’s more to this. There’s more to YOU.

Don’t give up now.

Not today.

You’re not done yet.

Tiredness will pass, and I want you to just try pushing through this. Just try. You’ll see you’re so capable of winning and it’ll blow your mind when you look back and realise the strength you truly possessed because you were able to push through.

Winning is your blood. It’s your oxygen.

Tiredness is a toxic. A poison. You’re not tired, you just think you are. When the human brain says it’s done, it’s actually got 70% more to give.

Don’t forget. Your legacy awaits. If this truly means everything to you, if you’ve already put in hundreds of hours of work into this, PUSH THROUGH! You’ve got to, because your future self deserves a better life! Don’t let them tell you that you need a break. A Hawaii vacation. They’ll say you’re getting nowhere and urge you to take a break.

You and me, we both know you don’t need one. You just needed a reminder of your capabilities.

And I’ve given you that now.

Just remember, you’re not done yet.

So fuck tiredness.

Go win.